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Dark spots and hyperpigmentation gradually fade, making previously uneven areas blend into the surrounding skin
It has been implicated in the pathogenesis of a range of diseases, including cancer, (5) metabolic disorders, (6) and reproductive conditions (7)
Coactivation of the metabolic regulatory factors PPAR and PGC-1 represents another important mechanism that alleviates ERS through multiple pathways, including enhanced lipid metabolism, reduced oxidative stress, and regulated gene transcription ( n = 16 elderly men) demonstrated that 12 weeks of resistance exercise training reduces ATF4 target genes (GADD45A, GADD34), implicating translational regulation of PERK signaling
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The full text of the selected articles were then reviewed by two independent researchers, examining study design, interventions, and outcomes in detail to determine eligibility
Funding Supported by grants from the National Natural Science Foundation of China (No
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